Our Science
Small Molecules Designed for Targeted Impact
Through our discovery approach, Ardelyx scientists have identified biological mechanisms that offer new ways to address significant unmet medical needs. We translate these insights into small molecule therapies designed to act on specific biological targets, with the goal of improving outcomes for patients.
Our Approach in Practice
NHE3 Inhibition:
Regulating Sodium and Fluid Balance
The sodium/hydrogen exchanger 3 (NHE3) is a key transporter responsible for sodium absorption in the intestines.
Our small molecule NHE3 inhibitor is designed to:
- Act locally in the gastrointestinal tract to minimize systemic absorption
- Reduce sodium uptake
- Increase water content in the intestinal lumen
- Improve downstream physiological function
Phosphate Absorption:
Addressing a Key Driver of CKD Complications
In patients with chronic kidney disease (CKD) on dialysis, elevated phosphate levels can contribute to serious health complications.
Our approach targets phosphate absorption by:
- Modulating transport pathways involved in phosphate uptake
- Decreasing phosphate absorption
- Acting at the site where phosphate enters the body
- Providing a first-in-class alternative mechanism of action
Designed for Precision and Practicality
A defining feature of our approach is the design of small molecules with targeted activity profiles.
This strategy is intended to:
- Focus therapeutic effect where it is most relevant
- Limit unnecessary systemic exposure
- Support use in chronic conditions
A Platform for Continued Innovation
Our expertise in small molecule design and transporter biology supports a growing pipeline across areas where these mechanisms play a central role. We are advancing programs in:
- Gastrointestinal disorders
- Renal and cardio-metabolic conditions
- Additional therapeutic areas where targeted modulation of biological pathways may provide benefit
Each program builds on a consistent foundation of mechanism-driven small molecule innovation.
We continue to advance our understanding of disease biology and use those insights to design innovative therapies. By combining deep scientific insight with focused drug design, we aim to deliver treatments that address important unmet medical needs.
Medicines
Ardelyx was founded to discover, develop, and commercialize innovative, novel mechanism therapies that address significant unmet medical needs.
Commitment to Patients
We believe in working closely with patients and their caregivers, listening to their needs and insights, and setting new standards in product innovation and community engagement.
US-COR-0097